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Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-...

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2538416868

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice

About this item

Full title

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice

Publisher

Durham: Research Square

Journal title

Alzheimer's Research and Therapy, 2020

Language

English

Publication information

Publisher

Durham: Research Square

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Background: Circulating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic autoimmunity, increased emotional reactivity, enhanced expression of the histone variant macroH2A1 in the cerebral...

Alternative Titles

Full title

Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2538416868

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2538416868

Other Identifiers

DOI

10.21203/rs.3.rs-60074/v2