Longitudinal Microglial Activation in Tau Transgenic P301S Mice Predicts Increased Tau Accumulation...
Longitudinal Microglial Activation in Tau Transgenic P301S Mice Predicts Increased Tau Accumulation and Deteriorated Spatial Learning
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Author / Creator
Eckenweber, Florian , Jose Medina Luque , Blume, Tanja , Sacher, Christian , Biechele, Gloria , Wind, Karin , Deussing, Maximilian , Briel, Nils , Lindner, Simon , Boening, Guido , Barbara von Ungern-Sternberg , Unterrainer, Marcus , Albert, Nathalie L , Zwergal, Andreas , Levin, Johannes , Bartenstein, Peter , Cumming, Paul , Rominger, Axel , Höglinger, Günter U , Herms, Jochen and Brendel, Matthias
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Durham: Research Square
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English
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Durham: Research Square
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Background: P301S tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. However, there is hitherto only sparse documentation of the role of neuroinflammation in tau mouse models. Thus, we analyzed longitudinal microglial activati...
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Full title
Longitudinal Microglial Activation in Tau Transgenic P301S Mice Predicts Increased Tau Accumulation and Deteriorated Spatial Learning
Authors, Artists and Contributors
Author / Creator
Jose Medina Luque
Blume, Tanja
Sacher, Christian
Biechele, Gloria
Wind, Karin
Deussing, Maximilian
Briel, Nils
Lindner, Simon
Boening, Guido
Barbara von Ungern-Sternberg
Unterrainer, Marcus
Albert, Nathalie L
Zwergal, Andreas
Levin, Johannes
Bartenstein, Peter
Cumming, Paul
Rominger, Axel
Höglinger, Günter U
Herms, Jochen
Brendel, Matthias
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TN_cdi_proquest_journals_2539459018
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2539459018
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DOI
10.21203/rs.3.rs-17790/v1
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https://www.proquest.com/docview/2539459018?pq-origsite=primo&accountid=13902
