Design, synthesis, and characterization of [18F]mG2P026 as a high contrast PET imaging ligand for me...
Design, synthesis, and characterization of [18F]mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
An array of triazolopyridines based on JNJ-46356479 (6) were synthesized as potential PET imaging ligands for metabotropic glutamate receptor 2 (mGluR2) in the brain. The selected candidates 8-11 featured an enhanced positive allosteric modulator (PAM) activity (37-fold max.) and an apparent mGluR2 agonist activity (25-fold max.) compared to compou...
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Full title
Design, synthesis, and characterization of [18F]mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2
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TN_cdi_proquest_journals_2547188891
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2547188891
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E-ISSN
2692-8205
DOI
10.1101/2021.06.29.450249
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https://www.proquest.com/docview/2547188891?pq-origsite=primo&accountid=13902
