Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice
Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice
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Berlin/Heidelberg: Springer Berlin Heidelberg
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Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Insulin deficiency or resistance can promote dementia and hallmarks of Alzheimer's disease (AD). The formation of neurofibrillary tangles of p-TAU protein, extracellular Aβ plaques, and neuronal loss is related to the switching off insulin signaling in cognition brain areas. Metformin is a biguanide antihyperglycemic drug used worldwide for the tre...
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Full title
Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice
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TN_cdi_proquest_journals_2573636891
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2573636891
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ISSN
0014-4819
E-ISSN
1432-1106
DOI
10.1007/s00221-021-06176-8
