The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local...
The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau misregulation and point mutations are linked to neurodegenerative diseases, including Progressive Sup...
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The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure
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TN_cdi_proquest_journals_2582478026
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2582478026
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E-ISSN
2692-8205
DOI
10.1101/2021.10.15.464588
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https://www.proquest.com/docview/2582478026?pq-origsite=primo&accountid=13902
