Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signature...
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
About this item
Full title
Author / Creator
Robinson, Philip S , Thomas, Laura E , Abascal, Federico , Jung, Hyunchul , Harvey, Luke , West, Hannah D , Olafsson, Sigurgeir , Lee, Bernard Ch , Coorens, Tim , Lee-Six, Henry , Butlin, Laura , Lander, Nicola , Sanders, Mathijs A , Lensing, Stefanie , Buczacki, Simon Ja , Rogier Ten Hoopen , Coleman, Nicholas , Brunton-Sim, Roxanne , Rushbrook, Simon , Saeb-Parsy, Kourosh , Lalloo, Fiona , Campbell, Peter J , Martincorena, Inigo , Sampson, Julian R and Stratton, Michael R
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal adenomas and carcinoma. However, the mechanistic progression from germline MUTYH mutations to MUTYH-Associated Polyposis (MAP) is...
Alternative Titles
Full title
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Authors, Artists and Contributors
Author / Creator
Thomas, Laura E
Abascal, Federico
Jung, Hyunchul
Harvey, Luke
West, Hannah D
Olafsson, Sigurgeir
Lee, Bernard Ch
Coorens, Tim
Lee-Six, Henry
Butlin, Laura
Lander, Nicola
Sanders, Mathijs A
Lensing, Stefanie
Buczacki, Simon Ja
Rogier Ten Hoopen
Coleman, Nicholas
Brunton-Sim, Roxanne
Rushbrook, Simon
Saeb-Parsy, Kourosh
Lalloo, Fiona
Campbell, Peter J
Martincorena, Inigo
Sampson, Julian R
Stratton, Michael R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2584123820
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2584123820
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.10.20.465093
How to access this item
https://www.proquest.com/docview/2584123820?pq-origsite=primo&accountid=13902
