Convergent somatic mutations in metabolism genes in chronic liver disease
Convergent somatic mutations in metabolism genes in chronic liver disease
About this item
Full title
Author / Creator
Ng, Stanley W. K. , Rouhani, Foad J. , Brunner, Simon F. , Brzozowska, Natalia , Aitken, Sarah J. , Yang, Ming , Abascal, Federico , Moore, Luiza , Nikitopoulou, Efterpi , Chappell, Lia , Leongamornlert, Daniel , Ivovic, Aleksandra , Robinson, Philip , Butler, Timothy , Sanders, Mathijs A. , Williams, Nicholas , Coorens, Tim H. H. , Teague, Jon , Raine, Keiran , Butler, Adam P. , Hooks, Yvette , Wilson, Beverley , Birtchnell, Natalie , Naylor, Huw , Davies, Susan E. , Stratton, Michael R. , Martincorena, Iñigo , Rahbari, Raheleh , Frezza, Christian , Hoare, Matthew and Campbell, Peter J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes
1
–
8
. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver disease
9
–
13
than in normal liver
13
–
16
, which enables positive s...
Alternative Titles
Full title
Convergent somatic mutations in metabolism genes in chronic liver disease
Authors, Artists and Contributors
Author / Creator
Rouhani, Foad J.
Brunner, Simon F.
Brzozowska, Natalia
Aitken, Sarah J.
Yang, Ming
Abascal, Federico
Moore, Luiza
Nikitopoulou, Efterpi
Chappell, Lia
Leongamornlert, Daniel
Ivovic, Aleksandra
Robinson, Philip
Butler, Timothy
Sanders, Mathijs A.
Williams, Nicholas
Coorens, Tim H. H.
Teague, Jon
Raine, Keiran
Butler, Adam P.
Hooks, Yvette
Wilson, Beverley
Birtchnell, Natalie
Naylor, Huw
Davies, Susan E.
Stratton, Michael R.
Martincorena, Iñigo
Rahbari, Raheleh
Frezza, Christian
Hoare, Matthew
Campbell, Peter J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2584793257
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2584793257
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03974-6
