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Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model...

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2602340095

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

About this item

Full title

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2021-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Synapse loss is associated with cognitive decline in Alzheimers disease (AD) and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta (Ab) around amyloid plaques is known to contribute to synapse loss in mouse models and is associated with synapse loss in human AD brain tissue, but the me...

Alternative Titles

Full title

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2602340095

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2602340095

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2021.11.24.469829