Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Dow...
Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimers Disease
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Microglia are critical for brain development and play a central role in Alzheimers disease (AD) etiology. Down syndrome (DS), also known as trisomy 21, is the most common genetic origin of intellectual disability and the most common risk factor for AD. Surprisingly, little information is available on the impact of trisomy of human chromosome 21 (Hs...
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Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimers Disease
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TN_cdi_proquest_journals_2613014729
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2613014729
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DOI
10.1101/2021.12.22.473858
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https://www.proquest.com/docview/2613014729?pq-origsite=primo&accountid=13902
