Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung c...
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The clinical success of immunotherapy that inhibits the negative immune regulatory pathway programmed cell death protein 1/PD-1 ligand (PD-1/PD-L1) has initiated a new era in the treatment of metastatic cancer. PD-L1 expression is upregulated in many solid tumors including lung cancer and functions predominantly in lactate-enriched tumor microenvir...
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Full title
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
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TN_cdi_proquest_journals_2615533444
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2615533444
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2017.188
