Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
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Author / Creator
Tuo, Q-z , Lei, P , Jackman, K A , Li, X-l , Xiong, H , Li, X-l , Liuyang, Z-y , Roisman, L , Zhang, S-t , Ayton, S , Wang, Q , Crouch, P J , Ganio, K , Wang, X-c , Pei, L , Adlard, P A , Lu, Y-m , Cappai, R , Wang, J-z , Liu, R and Bush, A I
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate ischemia–reperfusion-related toxicity. Indeed, unilateral, transient middle cerebral artery occlusion (MCAO) suppressed hemispheric tau and increased iron levels in y...
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Full title
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
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TN_cdi_proquest_journals_2615533643
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2615533643
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/mp.2017.171
