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Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress an...

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress an...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2619060863

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

About this item

Full title

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-01

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Tissue stem cells are hierarchically organized. Those that are most primitive serve as key drivers of regenerative response but the signals that selectively preserve their functional integrity are largely unknown. Here, we identify a secreted factor, Semaphorin 4A (Sema4A), as a specific regulator of myeloid-biased hematopoietic stem cells (myHSC),...

Alternative Titles

Full title

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2619060863

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2619060863

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.01.12.476097