Structural basis of GPBAR activation and bile acid recognition
Structural basis of GPBAR activation and bile acid recognition
About this item
Full title
Author / Creator
Yang, Fan , Mao, Chunyou , Guo, Lulu , Lin, Jingyu , Ming, Qianqian , Xiao, Peng , Wu, Xiang , Shen, Qingya , Guo, Shimeng , Shen, Dan-Dan , Lu, Ruirui , Zhang, Linqi , Huang, Shenming , Ping, Yuqi , Zhang, Chenlu , Ma, Cheng , Zhang, Kai , Liang, Xiaoying , Shen, Yuemao , Nan, Fajun , Yi, Fan , Luca, Vincent C. , Zhou, Jiuyao , Jiang, Changtao , Sun, Jin-Peng , Xie, Xin , Yu, Xiao and Zhang, Yan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The G-protein-coupled bile acid receptor (GPBAR) conveys the cross-membrane signalling of a vast variety of bile acids and is a signalling hub in the liver–bile acid–microbiota–metabolism axis
1
–
3
. Here we report the cryo-electron microscopy structures of GPBAR–G
s
complexes stabilized by either the high-affinity P395
4
o...
Alternative Titles
Full title
Structural basis of GPBAR activation and bile acid recognition
Authors, Artists and Contributors
Author / Creator
Mao, Chunyou
Guo, Lulu
Lin, Jingyu
Ming, Qianqian
Xiao, Peng
Wu, Xiang
Shen, Qingya
Guo, Shimeng
Shen, Dan-Dan
Lu, Ruirui
Zhang, Linqi
Huang, Shenming
Ping, Yuqi
Zhang, Chenlu
Ma, Cheng
Zhang, Kai
Liang, Xiaoying
Shen, Yuemao
Nan, Fajun
Yi, Fan
Luca, Vincent C.
Zhou, Jiuyao
Jiang, Changtao
Sun, Jin-Peng
Xie, Xin
Yu, Xiao
Zhang, Yan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2626302971
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2626302971
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2569-1
