Surface interaction patches link non-specific binding and phase separation of antibodies
Surface interaction patches link non-specific binding and phase separation of antibodies
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Non-specificity is a key challenge in the successful development of therapeutic antibodies. The tendency for non-specific binding in antibodies is often difficult to reduce via judicious design and, instead, it is necessary to rely on comprehensive screening campaigns. A better understanding of the molecular origins that drive antibody non-specific...
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Full title
Surface interaction patches link non-specific binding and phase separation of antibodies
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TN_cdi_proquest_journals_2637040942
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2637040942
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E-ISSN
2692-8205
DOI
10.1101/2022.03.07.483238
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https://www.proquest.com/docview/2637040942?pq-origsite=primo&accountid=13902