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Surface interaction patches link non-specific binding and phase separation of antibodies

Surface interaction patches link non-specific binding and phase separation of antibodies

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2637040942

Surface interaction patches link non-specific binding and phase separation of antibodies

About this item

Full title

Surface interaction patches link non-specific binding and phase separation of antibodies

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-03

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Non-specificity is a key challenge in the successful development of therapeutic antibodies. The tendency for non-specific binding in antibodies is often difficult to reduce via judicious design and, instead, it is necessary to rely on comprehensive screening campaigns. A better understanding of the molecular origins that drive antibody non-specific...

Alternative Titles

Full title

Surface interaction patches link non-specific binding and phase separation of antibodies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2637040942

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2637040942

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.03.07.483238