EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene act...
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3 deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 has additional noncanonical functions by binding cMyc at non-PRC2 targets and uses a hidden transactivation domain (TAD) for (co)activator recruitment and gene activation. Both...
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EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
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TN_cdi_proquest_journals_2639130477
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2639130477
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-022-00850-x
