Inhibition of Prekallikrein for Hereditary Angioedema
Inhibition of Prekallikrein for Hereditary Angioedema
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Author / Creator
Fijen, Lauré M , Riedl, Marc A , Bordone, Laura , Bernstein, Jonathan A , Raasch, Jason , Tachdjian, Raffi , Craig, Timothy , Lumry, William R , Manning, Michael E , Alexander, Veronica J , Newman, Kenneth B , Revenko, Alexey , Baker, Brenda F , Nanavati, Charvi , MacLeod, A. Robert , Schneider, Eugene and Cohn, Danny M
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
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Scope and Contents
Contents
Hereditary angioedema with C1 inhibitor deficiency, characterized by unpredictable and occasionally fatal swellings, is caused by uncontrolled activity of factor XIIa and plasma kallikrein, leading to locally increased vascular permeability. In a small, randomized, controlled trial, an antisense oligonucleotide drug targeting prekallikrein suppress...
Alternative Titles
Full title
Inhibition of Prekallikrein for Hereditary Angioedema
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_journals_2640093417
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2640093417
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2109329
