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Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) p...

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) p...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2659404968

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

About this item

Full title

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Huntington disease (HD) is a neurodegerative disorder caused by an inherited unstable HTT CAG repeat that expands further, thereby eliciting a disease process that may be initiated by polyglutamine-expanded huntingtin or a short polyglutamine-product. Phosphorylation of selected candidate residues is reported to mediate polyglutamine-fragment degra...

Alternative Titles

Full title

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2659404968

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2659404968

Other Identifiers

DOI

10.1101/2022.05.04.490694