ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in m...
ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Genomic instability contributes to cancer progression and is at least partly due to dysregulated homologous recombination. Here, we show that an elevated level of ABL1 kinase overactivates the HR pathway and causes genomic instability in multiple myeloma (MM) cells. Inhibiting ABL1 with either shRNA or a pharmacological inhibitor (nilotinib) inhibi...
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Full title
ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma
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TN_cdi_proquest_journals_2663810882
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2663810882
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E-ISSN
2692-8205
DOI
10.1101/2022.05.12.491727
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https://www.proquest.com/docview/2663810882?pq-origsite=primo&accountid=13902
