TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
About this item
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Author / Creator
Pérez-Berlanga, Manuela , Wiersma, Vera I , Zbinden, Aurélie , De Vos, Laura , Wagner, Ulrich , Foglieni, Chiara , Mallona, Izaskun , Betz, Katharina M , Cléry, Antoine , Weber, Julien , Guo, Zhongning , Rigort, Ruben , De Rossi, Pierre , Manglunia, Ruchi , Tantardini, Elena , Sahadevan, Sonu , Stach, Oliver , Hruska-Plochan, Marian , Allain, Frederic H-T , Paganetti, Paolo and Polymenidou, Magdalini
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Aggregation of the RNA-binding protein TDP-43 is the main common neuropathological feature of TDP-43 proteinopathies. In physiological conditions, TDP-43 is predominantly nuclear and contained in biomolecular condensates formed via liquid-liquid phase separation (LLPS). However, in disease, TDP-43 is depleted from these compartments and forms cytop...
Alternative Titles
Full title
TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
Authors, Artists and Contributors
Author / Creator
Wiersma, Vera I
Zbinden, Aurélie
De Vos, Laura
Wagner, Ulrich
Foglieni, Chiara
Mallona, Izaskun
Betz, Katharina M
Cléry, Antoine
Weber, Julien
Guo, Zhongning
Rigort, Ruben
De Rossi, Pierre
Manglunia, Ruchi
Tantardini, Elena
Sahadevan, Sonu
Stach, Oliver
Hruska-Plochan, Marian
Allain, Frederic H-T
Paganetti, Paolo
Polymenidou, Magdalini
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2669224745
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2669224745
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E-ISSN
2692-8205
DOI
10.1101/2022.05.23.493029
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https://www.proquest.com/docview/2669224745?pq-origsite=primo&accountid=13902
