Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following...
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
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Author / Creator
Magen, Assaf , Hamon, Pauline , Fiaschi, Nathalie , Troncoso, Leanna , Humblin, Etienne , D'souza, Darwin , Dawson, Travis , Park, Matthew D , Kim, Joel , Hamel, Steven , Buckup, Mark , Chang, Christie , Tabachnikova, Alexandra , Schwartz, Hara , Malissen, Nausicaa , Lavin, Yonit , Soares-Schanoski, Alessandra , Giotti, Bruno , Hegde, Samarth , Mattiuz, Raphael , Hennequin, Clotilde , Jessica Le Berichel , Zhao, Zhen , Ward, Stephen , Fiel, Isabel , Price, Colles , Fernandez, Nicolas , He, Jiang , Kou, Baijun , Dobosz, Michael , Li, Lianjie , Adler, Christina , Ni, Min , Wei, Yi , Wang, Wei , Gupta, Namita T , Kundu, Kunal , Cygan, Kamil , Deering, Raquel P , Tsankov, Alex , Kim-Schulze, Seunghee , Gnjatic, Sacha , Kenigsberg, Ephraim , Schwartz, Myron , Marron, Thomas U , Thurston, Gavin , Kamphorst, Alice O and Merad, Miriam
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Here, we leveraged a large neoadjuvant PD-1 blockade trial in patients with hepatocellular carcinoma (HCC) to search for correlates of response to immune checkpoint blockade (ICB) within T cell-rich tumors. We show that ICB response correlated with the clonal expansion of intratumoral CXCL13+ CH25H+ IL-21+ PD-1+ CD4 T helper cells (CXCL13+ Th) and...
Alternative Titles
Full title
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
Authors, Artists and Contributors
Author / Creator
Hamon, Pauline
Fiaschi, Nathalie
Troncoso, Leanna
Humblin, Etienne
D'souza, Darwin
Dawson, Travis
Park, Matthew D
Kim, Joel
Hamel, Steven
Buckup, Mark
Chang, Christie
Tabachnikova, Alexandra
Schwartz, Hara
Malissen, Nausicaa
Lavin, Yonit
Soares-Schanoski, Alessandra
Giotti, Bruno
Hegde, Samarth
Mattiuz, Raphael
Hennequin, Clotilde
Jessica Le Berichel
Zhao, Zhen
Ward, Stephen
Fiel, Isabel
Price, Colles
Fernandez, Nicolas
He, Jiang
Kou, Baijun
Dobosz, Michael
Li, Lianjie
Adler, Christina
Ni, Min
Wei, Yi
Wang, Wei
Gupta, Namita T
Kundu, Kunal
Cygan, Kamil
Deering, Raquel P
Tsankov, Alex
Kim-Schulze, Seunghee
Gnjatic, Sacha
Kenigsberg, Ephraim
Schwartz, Myron
Marron, Thomas U
Thurston, Gavin
Kamphorst, Alice O
Merad, Miriam
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2681057434
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2681057434
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.06.22.497216
How to access this item
https://www.proquest.com/docview/2681057434?pq-origsite=primo&accountid=13902
