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Radiochemical Synthesis and Evaluation of 3-[11C]methyl-4-aminopyridine in Rodents and Non-Human Pri...

Radiochemical Synthesis and Evaluation of 3-[11C]methyl-4-aminopyridine in Rodents and Non-Human Pri...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2681057653

Radiochemical Synthesis and Evaluation of 3-[11C]methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

About this item

Full title

Radiochemical Synthesis and Evaluation of 3-[11C]methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-06

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinated neurons, the axonal potassium channels Kv1.1 and Kv1.2, normally under the myelin sheath, become...

Alternative Titles

Full title

Radiochemical Synthesis and Evaluation of 3-[11C]methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2681057653

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2681057653

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2022.06.22.495540