Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
About this item
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Author / Creator
Basu, Shaon , Martinez-Cristobal, Paula , Pesarrodona, Mireia , Frigole-Vivas, Marta , Szulc, Elzbieta , Lewis, Michael , Banuelos, Adriana , Sanchez-Zarzalejo, Carolina , Bielskute, Stase , Zhu, Jiaqi , Pombo-Garcia, Karina , Garcia-Cabau, Carla , Batlle, Cristina , Mateos, Borja , Biesaga, Mateusz , Escobedo, Albert , Bardia, Lidia , Verdaguer, Xavier , Ruffoni, Alessandro , Mawji, Nasrin R , Wang, Juan , Tam, Teresa , Brun-Heath, Isabelle , Ventura, Salvador , Meierhofer, David , Garcia, Jesus , Robustelli, Paul , Stracker, Travis H , Sadar, Marianne D , Riera, Antoni , Hnisz, Denes and Salvatella, Xavier
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Transcription factors are among the most attractive therapeutic targets but are considered largely undruggable due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration resistant prostate cancer, is key for i...
Alternative Titles
Full title
Rational optimization of a transcription factor activation domain inhibitor
Authors, Artists and Contributors
Author / Creator
Martinez-Cristobal, Paula
Pesarrodona, Mireia
Frigole-Vivas, Marta
Szulc, Elzbieta
Lewis, Michael
Banuelos, Adriana
Sanchez-Zarzalejo, Carolina
Bielskute, Stase
Zhu, Jiaqi
Pombo-Garcia, Karina
Garcia-Cabau, Carla
Batlle, Cristina
Mateos, Borja
Biesaga, Mateusz
Escobedo, Albert
Bardia, Lidia
Verdaguer, Xavier
Ruffoni, Alessandro
Mawji, Nasrin R
Wang, Juan
Tam, Teresa
Brun-Heath, Isabelle
Ventura, Salvador
Meierhofer, David
Garcia, Jesus
Robustelli, Paul
Stracker, Travis H
Sadar, Marianne D
Riera, Antoni
Hnisz, Denes
Salvatella, Xavier
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2704121299
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2704121299
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.08.18.504385
How to access this item
https://www.proquest.com/docview/2704121299?pq-origsite=primo&accountid=13902
