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Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhe...

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhe...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2709801845

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

About this item

Full title

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

Publisher

United States: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2022-09

Language

English

Formats

Publication information

Publisher

United States: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnupiravir (MK-4482), a nucleoside analog, and nirmatrelvir (PF-07321332), a 3C-like protease inhibitor, have each...

Alternative Titles

Full title

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2709801845

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2709801845

Other Identifiers

ISSN

2692-8205

E-ISSN

2692-8205

DOI

10.1101/2022.09.03.506479