Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibit...
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
About this item
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Author / Creator
Mhlekude, Baxolele , Postmus, Dylan , Weiner, January , Stenzel, Saskia , Zapatero-Belinchon, Francisco J , Olmer, Ruth , Jansen, Jenny , Richter, Anja , Heinze, Julian , Heinemann, Nicolas , Muhlemann, Barbara , Schroeder, Simon , Jones, Terry C , Muller, Marcel Alexander , Drosten, Christian , Pich, Andreas , Thiel, Volker , Martin, Ulrich , Niemeyer, Daniela , Gerold, Gisa , Beule, Dieter and Goffinet, Christine
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential therapeutics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-induced antiviral activity and its susceptibility to viral antagonism remain incompletely understood. iBET treatment transiently inhibited infection...
Alternative Titles
Full title
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
Authors, Artists and Contributors
Author / Creator
Postmus, Dylan
Weiner, January
Stenzel, Saskia
Zapatero-Belinchon, Francisco J
Olmer, Ruth
Jansen, Jenny
Richter, Anja
Heinze, Julian
Heinemann, Nicolas
Muhlemann, Barbara
Schroeder, Simon
Jones, Terry C
Muller, Marcel Alexander
Drosten, Christian
Pich, Andreas
Thiel, Volker
Martin, Ulrich
Niemeyer, Daniela
Gerold, Gisa
Beule, Dieter
Goffinet, Christine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2717189117
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2717189117
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2022.09.22.508962
How to access this item
https://www.proquest.com/docview/2717189117?pq-origsite=primo&accountid=13902
