Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4BG12V and Rgl2,...
Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs), play an essential role in oncogenic Ras-induced signalling. We studied the interaction between human K-Ras4B and the Ras binding domain (RB...
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Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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TN_cdi_proquest_journals_2723284254
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2723284254
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DOI
10.1101/2022.10.10.511529
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https://www.proquest.com/docview/2723284254?pq-origsite=primo&accountid=13902
