Synthesis and Testing of Analogs of the Tuberculosis Drug SQ109 Against Bacteria and Protozoa: Ident...
Synthesis and Testing of Analogs of the Tuberculosis Drug SQ109 Against Bacteria and Protozoa: Identification of Lead Compounds Against Mycobacterium abscessus and Malaria
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Author / Creator
Stampolaki, Marianna , Malwal, Satish , Alvarez, Nadine , Gao, Zijun , Moniruzzaman, Mohammad , Babii, Svitlana , Naziris, Nikolaos , Rey-Cibati, André , Valladares-Delgado, Mariana , Turcu, Andreea , Kyung-Hwa Baek , Lee, Hyeryon , Alcaraz, Matthéo , Watson, Savannah , van der Watt, Mariëtte , Coertzen, Dina , Efstathiou, Natasa , Stylianakis, Ioannis , Chountoulesi, Maria , Schoen, Carolyn , Papanastasiou, Ioannis , Brea, José , Cynamon, Michael , Lyn-Marie Birkholtz , Kremer, Laurent , Joo Hwan No , Vazquez, Santiago , Benaim, Gustavo , Demetzos, Costas , Zgurskaya, Helen , Dick, Thomas , Oldfield, Eric and Kolocouris, Antonios
Publisher
Washington: American Chemical Society
Journal title
Language
English
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Publication information
Publisher
Washington: American Chemical Society
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More information
Scope and Contents
Contents
SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has activity against bacteria and protozoan parasites that lack MmpL3, where it can act as an uncoupler, targeting lipid membranes...
Alternative Titles
Full title
Synthesis and Testing of Analogs of the Tuberculosis Drug SQ109 Against Bacteria and Protozoa: Identification of Lead Compounds Against Mycobacterium abscessus and Malaria
Authors, Artists and Contributors
Author / Creator
Malwal, Satish
Alvarez, Nadine
Gao, Zijun
Moniruzzaman, Mohammad
Babii, Svitlana
Naziris, Nikolaos
Rey-Cibati, André
Valladares-Delgado, Mariana
Turcu, Andreea
Kyung-Hwa Baek
Lee, Hyeryon
Alcaraz, Matthéo
Watson, Savannah
van der Watt, Mariëtte
Coertzen, Dina
Efstathiou, Natasa
Stylianakis, Ioannis
Chountoulesi, Maria
Schoen, Carolyn
Papanastasiou, Ioannis
Brea, José
Cynamon, Michael
Lyn-Marie Birkholtz
Kremer, Laurent
Joo Hwan No
Vazquez, Santiago
Benaim, Gustavo
Demetzos, Costas
Zgurskaya, Helen
Dick, Thomas
Oldfield, Eric
Kolocouris, Antonios
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2730387254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2730387254
Other Identifiers
E-ISSN
2573-2293
DOI
10.26434/chemrxiv-2022-xm94p
