SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing
SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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SARS-CoV-2 proteins are translated from subgenomic RNAs (sgRNAs). While most of these sgRNAs are monocistronic, some viral mRNAs encode more than one protein. For example, the ORF3a sgRNA also encodes ORF3c, an enigmatic 41-amino acid peptide. Here, we show that ORF3c suppresses RIG-I- and MDA5-mediated immune activation and interacts with the sign...
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Full title
SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing
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TN_cdi_proquest_journals_2781019072
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2781019072
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DOI
10.1101/2023.02.27.530232
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https://www.proquest.com/docview/2781019072?pq-origsite=primo&accountid=13902
