Three-dimensional quantitative structural-activity relationship and molecular dynamics study of mult...
Three-dimensional quantitative structural-activity relationship and molecular dynamics study of multivariate substituted 4-oxyquinazoline HDAC6 inhibitors
About this item
Full title
Author / Creator
Zhao, Linan , Fu, Le , Li, Guangping , Yu, Yongxin , Wang, Juan , Liang, Haoran , Shu, Mao , Lin, Zhihua and Wang, Yuanqiang
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
3D-QSAR models were established by collecting 46 multivariate-substituted 4-oxyquinazoline HDAC6 inhibitors. The relationship of molecular structure and inhibitory activity was studied by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA). The results showed the models established by CoMFA (
Alternative Titles
Full title
Three-dimensional quantitative structural-activity relationship and molecular dynamics study of multivariate substituted 4-oxyquinazoline HDAC6 inhibitors
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2827006844
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2827006844
Other Identifiers
ISSN
1381-1991
E-ISSN
1573-501X
DOI
10.1007/s11030-022-10474-w
