Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
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Author / Creator
Flønes, Irene H , Toker, Lilah , Sandnes, Dagny Ann , Castelli, Martina , Mostafavi, Sepideh , Njål Lura , Shadad, Omnia , Fernandez-Vizarra, Erika , Painous, Cèlia , Pérez-Soriano, Alexandra , Compta, Yaroslau , Molina-Porcel, Laura , Alves, Guido , Ole-Bjørn Tysnes , Dölle, Christian , Nido, Gonzalo S and Tzoulis, Charalampos
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
AbstractIdiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory complex I (CI) deficiency, and identify two emerging disease subtypes with distinct molecular and clinic...
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Full title
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
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TN_cdi_proquest_journals_2895047403
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2895047403
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E-ISSN
2692-8205
DOI
10.1101/2023.09.22.558615
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https://www.proquest.com/docview/2895047403?pq-origsite=primo&accountid=13902
