Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in...
Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice
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United States: Cold Spring Harbor Laboratory Press
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English
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United States: Cold Spring Harbor Laboratory Press
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Genetic variants in TRIO are associated with neurodevelopmental disorders (NDDs) including schizophrenia (SCZ), autism spectrum disorder (ASD) and intellectual disability. TRIO uses its two guanine nucleotide exchange factor (GEF) domains to activate GTPases (GEF1: Rac1 and RhoG; GEF2: RhoA) that control neuronal development and connectivity. It re...
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Full title
Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice
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TN_cdi_proquest_journals_2910880894
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2910880894
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ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.01.05.574442
