Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfuncti...
Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice
About this item
Full title
Author / Creator
Romay, Milagros C , Knutsen, Russell H , Ma, Feiyang , Mompeón, Ana , Hernandez, Gloria E , Salvador, Jocelynda , Mirkov, Snezana , Batra, Ayush , Sullivan, David R , Procissi, Daniele , Buchanan, Samuel , Kronquist, Elise , Ferrante, Elisa A , Muller, William A , Walshon, Jordain , Steffens, Alicia , McCortney, Kathleen , Horbinski, Craig , Tournier-Lasserve, Elisabeth , Sonabend, Adam M , Sorond, Farzaneh A , Wang, Michael M , Boehm, Manfred , Kozel, Beth A and Iruela-arispe, M Luisa
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in bo...
Alternative Titles
Full title
Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice
Authors, Artists and Contributors
Author / Creator
Knutsen, Russell H
Ma, Feiyang
Mompeón, Ana
Hernandez, Gloria E
Salvador, Jocelynda
Mirkov, Snezana
Batra, Ayush
Sullivan, David R
Procissi, Daniele
Buchanan, Samuel
Kronquist, Elise
Ferrante, Elisa A
Muller, William A
Walshon, Jordain
Steffens, Alicia
McCortney, Kathleen
Horbinski, Craig
Tournier-Lasserve, Elisabeth
Sonabend, Adam M
Sorond, Farzaneh A
Wang, Michael M
Boehm, Manfred
Kozel, Beth A
Iruela-arispe, M Luisa
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2929145790
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2929145790
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI166134.
