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p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasi...

p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3111573962

p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus

About this item

Full title

p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus

Publisher

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Journal title

Gut, 2025-02, Vol.74 (2), p.182-196

Language

English

Formats

Publication information

Publisher

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

More information

Scope and Contents

Contents

BackgroundWhile p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear.ObjectiveThis study investigates the impact of p53 mutation on the fate and function of cardia progenitor cells in BE to EAC progression, particularly under the duress of chr...

Alternative Titles

Full title

p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3111573962

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3111573962

Other Identifiers

ISSN

0017-5749,1468-3288

E-ISSN

1468-3288

DOI

10.1136/gutjnl-2024-332095

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