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Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3131626271

Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

About this item

Full title

Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2024-11

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The persistence of adoptively transferred T cells is vital for anti-tumor efficacy. Chimeric antigen receptor (CAR) T cells can persist indefinitely when delivered to patients with B cell cancers and can confer long-term remission. For patients with solid tumors, however, sustaining CAR T cell activity remains a major challenge. This has been attri...

Alternative Titles

Full title

Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3131626271

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3131626271

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2024.11.19.624339