Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity...
Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers
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Ithaca: Cornell University Library, arXiv.org
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English
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Ithaca: Cornell University Library, arXiv.org
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Contents
Conventionally, a first-in-human phase I trial in healthy volunteers aims to confirm the safety of a drug in humans. In such situations, volunteers should not suffer from any safety issues and simple algorithm-based dose-escalation schemes are often used. However, to avoid too many clinical trials in the future, it might be appealing to design thes...
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Full title
Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers
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TN_cdi_proquest_journals_3141255138
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3141255138
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E-ISSN
2331-8422
DOI
10.48550/arxiv.2412.03298
