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Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stag...

Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stag...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3159711419

Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation

About this item

Full title

Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation

Publisher

United States: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2025-01

Language

English

Formats

Publication information

Publisher

United States: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Cortical dysfunction is increasingly recognized as a major contributor to the non-motor symptoms associated with Parkinson's disease (PD) and other synucleinopathies. Although functional alterations in cortical circuits have been observed in preclinical PD models, the underlying molecular mechanisms are unclear. To bridge this knowledge gap, we inv...

Alternative Titles

Full title

Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3159711419

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3159711419

Other Identifiers

ISSN

2692-8205

E-ISSN

2692-8205

DOI

10.1101/2025.01.24.634820