Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticl...
Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Ionizable Lipid Nanoparticles (LNPs) are an FDA-approved non-viral RNA delivery system, though their use for brain therapy is restricted by the blood-brain barrier (BBB). Focused ultrasound combined with microbubbles can disrupt the BBB, but delivering large particles requires balancing increased peak negative pressures while maintaining microvascu...
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Full title
Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma
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TN_cdi_proquest_journals_3159904988
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3159904988
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E-ISSN
2692-8205
DOI
10.1101/2025.01.23.634427
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https://www.proquest.com/docview/3159904988?pq-origsite=primo&accountid=13902
