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Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB k...

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB k...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3163040488

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

About this item

Full title

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2025-02

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

CYLD cutaneous syndrome (CCS) skin tumors develop from puberty onwards, can number in the hundreds and progressively grow over time. CCS patients lack medical therapies and require repeated surgery to control tumor burden. CYLD loss of heterozygosity (LOH) drives tumor growth, and CCS tumors have previously been shown to demonstrate increased canon...

Alternative Titles

Full title

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_3163040488

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3163040488

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2025.01.31.635629