Anti-Parasitics with a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host...
Anti-Parasitics with a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing
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Author / Creator
Pandey, Akanksha M , Malwal, Satish R , Valladares-Delgado, Mariana , Labrador-Fagundez, Liesangerli , Stella, Bruno G , Diaz-Perez, Luis Jose , Rey-Cibati, Andre , Singh, Davinder , Stampolaki, Marianna , Hong, Sangjin , Gennis, Robert B , Kolocouris, Antonios D , Benaim, Gustavo and Oldfield, Eric
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
We investigated the effects of the tuberculosis drug candidate SQ109 (8a) and of its analog MeSQ109 (8b) against Leishmania mexicana in promastigote and amastigote forms, as well as against host cell macrophages finding potent activity (1.7 nM) for MeSQ109 against the intracellular forms, as well as low toxicity (~61 muM) to host cells, resulting i...
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Full title
Anti-Parasitics with a Triple Threat: Targeting Parasite Enzymes, the Proton Motive Force, and Host Cell-Mediated Killing
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Record Identifier
TN_cdi_proquest_journals_3163292516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3163292516
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E-ISSN
2692-8205
DOI
10.1101/2025.02.03.636145
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https://www.proquest.com/docview/3163292516?pq-origsite=primo&accountid=13902
