Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA
Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA
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Publisher
United States: Oxford University Press
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Language
English
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United States: Oxford University Press
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Contents
The human APOBEC3 gene cluster locus encodes polynucleotide cytidine deaminases. Although many act as viral restriction factors through mutation of single-stranded DNA, recent reports have shown that human APOBEC3A was capable of efficiently hypermutating nuclear DNA and inducing DNA breaks in genomic DNA. In addition, the enzyme was unique in effi...
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Full title
Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA
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TN_cdi_proquest_journals_3171261578
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3171261578
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ISSN
0737-4038
E-ISSN
1537-1719
DOI
10.1093/molbev/mst195
