Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) are key regulators of the G1-S phase transition in the cell cycle. In cancer cells, CDK6 overexpression often outcompetes CDK4 in driving cell cycle progression, contributing to resistance against CDK4/6 inhibitors (CDK4/6i). This suggests distinct functional and conformational differences between th...
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Full title
Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
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TN_cdi_proquest_journals_3173596027
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3173596027
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DOI
10.1101/2025.02.28.640857
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https://www.proquest.com/docview/3173596027?pq-origsite=primo&accountid=13902
