Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8
Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Missense variants can have pleiotropic effects on protein function and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled receptor that promotes germinal center B cell confinement. We assayed the effect of each variant on surface expression, migration, and proliferation. We...
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Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8
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TN_cdi_proquest_journals_3174601667
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_3174601667
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DOI
10.1101/2025.02.28.640567
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https://www.proquest.com/docview/3174601667?pq-origsite=primo&accountid=13902
