Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy...
Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects
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Publisher
Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
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Language
English
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Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
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Purpose Ezetimibe is the first lipid-lowering drug that inhibits the intestinal uptake of dietary and biliary cholesterol without affecting the absorption of fat-soluble nutrients. Ezetimibe is readily absorbed, and undergoes rapid and almost complete glucuronidation by UGT, particularly UGT1A1, in enterocytes during its first pass. Genetic polymor...
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Full title
Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects
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TN_cdi_proquest_journals_821742792
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_821742792
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ISSN
0031-6970
E-ISSN
1432-1041
DOI
10.1007/s00228-010-0899-x
