Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET sign...
Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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The receptor tyrosine kinase MET is frequently amplified in human tumors, resulting in high cell surface densities and constitutive activation even in the absence of growth factor stimulation by its endogenous ligand, hepatocyte growth factor (HGF). We sought to identify mechanisms of signaling crosstalk that promote MET activation by searching for...
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Full title
Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
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TN_cdi_proquest_journals_848011540
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_848011540
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1012500108
