Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cance...
Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
About this item
Full title
Author / Creator
Scaltriti, Maurizio , Eichhorn, Pieter J , Cortés, Javier , Prudkin, Ludmila , Aura, Claudia , Jiménez, José , Chandarlapaty, Sarat , Serra, Violeta , Prat, Aleix , Ibrahim, Yasir H , Guzmán, Marta , Gili, Magui , Rodríguez, Olga , Rodríguez, Sonia , Pérez, José , Green, Simon R , Mai, Sabine , Rosen, Neal , Hudis, Clifford and Baselga, José
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Clinical benefits from trastuzumab and other anti-HER2 therapies in patients with HER2 amplified breast cancer remain limited by primary or acquired resistance. To identify potential mechanisms of resistance, we established trastuzumab-resistant HER2 amplified breast cancer cells by chronic exposure to trastuzumab treatment. Genomewide copy-number...
Alternative Titles
Full title
Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
Authors, Artists and Contributors
Author / Creator
Eichhorn, Pieter J
Cortés, Javier
Prudkin, Ludmila
Aura, Claudia
Jiménez, José
Chandarlapaty, Sarat
Serra, Violeta
Prat, Aleix
Ibrahim, Yasir H
Guzmán, Marta
Gili, Magui
Rodríguez, Olga
Rodríguez, Sonia
Pérez, José
Green, Simon R
Mai, Sabine
Rosen, Neal
Hudis, Clifford
Baselga, José
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_854949449
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_854949449
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1014835108
