Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Rece...
Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor
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Publisher
Boston: Springer US
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Language
English
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Publisher
Boston: Springer US
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ABSTRACT
Purpose
For AMG 317, a fully human monoclonal antibody to interleukin receptor IL-4Rα, we developed a population pharmacokinetic (PK) model by fitting data from four early phase clinical trials of intravenous and subcutaneous (SC) routes simultaneously, investigated important PK covariates, and explored the relationship between expos...
Alternative Titles
Full title
Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor
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TN_cdi_proquest_journals_888246760
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_888246760
Other Identifiers
ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-011-0481-y
