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ArticlesPeer ReviewedFull Text
Approximations of the target-mediated drug disposition model and identifiability of model parameters
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina ; Kakkar, Tarundeep ; Ma, Peiming
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2008-10, Vol.35 (5), p.573-591
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Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate
Author / Creator:Pouzin, Clemence ; Gibiansky, Leonid ; Fagniez, Nathalie ; Chadjaa, Mustapha ; Tod, Michel ; Nguyen, Laurent
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2022-06, Vol.49 (3), p.381-394
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Population pharmacokinetic and exposure–response analyses of intravenous and subcutaneous rituximab in patients with chronic lymphocytic leukemia
Author / Creator:Gibiansky, Ekaterina ; Gibiansky, Leonid ; Chavanne, Clarisse ; Frey, Nicolas ; Jamois, Candice
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2021-08, Vol.10 (8), p.914-927
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Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-H...
Author / Creator:Lu, Dan ; Lu, Tong ; Shi, Rong ; Gibiansky, Leonid ; Agarwal, Priya ; Shemesh, Colby S. ; Dere, Randall C. ; Ogbu, Uzor ; Hirata, Jamie ; Chanu, Pascal ; Girish, Sandhya ; Jin, Jin Yan ; Li, Chunze ; Miles, Dale
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2020-12, Vol.37 (12), p.252, Article 252
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Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
Author / Creator:Shi, Rong ; Lu, Tong ; Ku, Grace ; Ding, Hao ; Saito, Tomohisa ; Gibiansky, Leonid ; Agarwal, Priya ; Li, Xiaobin ; Jin, Jin Yan ; Girish, Sandhya ; Miles, Dale ; Li, Chunze ; Lu, Dan
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2020-09, Vol.86 (3), p.347-359
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Exposure-safety and exposure-efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors
Author / Creator:Passey, Chaitali ; Voellinger, Jenna ; Gibiansky, Leonid ; Gunawan, Rudy ; Nicacio, Leonardo ; Soumaoro, Ibrahima ; Hanley, William D ; Winter, Helen ; Gupta, Manish
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-09, Vol.12 (9), p.1262-1273
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Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody
Author / Creator:Wang, Ellen Q. ; Kaila, Nitin ; Plowchalk, David ; Gibiansky, Leonid ; Yunis, Carla ; Sweeney, Kevin
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-12, Vol.12 (12), p.2013-2026
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ArticlesPeer ReviewedFull Text
Population pharmacokinetic analysis for tisotumab vedotin in patients with locally advanced and/or metastatic solid tumors
Author / Creator:Gibiansky, Leonid ; Passey, Chaitali ; Voellinger, Jenna ; Gunawan, Rudy ; Hanley, William D. ; Gupta, Manish ; Winter, Helen
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-10, Vol.11 (10), p.1358-1370
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Rituximab pediatric drug development: Pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with granulomatosis with polyangiitis or microscopi...
Author / Creator:Jamois, Candice ; Gibiansky, Leonid ; Chavanne, Clarisse ; Cheu, Melissa ; Lehane, Patricia B. ; Pordeli, Pooneh ; Melega, Simone ; Gaudreault, Jacques
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2022-09, Vol.15 (9), p.2172-2183
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Ethnic sensitivity assessment: Polatuzumab vedotin pharmacokinetics in Asian and non‐Asian patients with previously untreated diffuse large B‐cell lymphoma in POLARIX
Author / Creator:Liao, Michael Z. ; Deng, Rong ; Gibiansky, Leonid ; Lu, Tong ; Agarwal, Priya ; Dere, Randall ; Lee, Calvin ; Hirata, Jamie ; Herbaux, Charles ; Salles, Gilles ; Li, Chunze ; Miles, Dale
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2023-12, Vol.16 (12), p.2744-2755
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ArticlesPeer ReviewedFull Text
Population pharmacokinetics and exposure–response analyses of polatuzumab vedotin in patients with previously untreated DLBCL from the POLARIX study
Author / Creator:Deng, Rong ; Gibiansky, Leonid ; Lu, Tong ; Flowers, Christopher R. ; Sehn, Laurie H. ; Liu, Qi ; Agarwal, Priya ; Liao, Michael Z. ; Dere, Randall ; Lee, Calvin ; Man, Gabriel ; Hirata, Jamie ; Li, Chunze ; Miles, Dale
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-06, Vol.13 (6), p.1055-1066
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ArticlesPeer ReviewedFull Text
Integrated Two‐Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non‐Hodgkin Lymphoma
Author / Creator:Lu, Dan ; Lu, Tong ; Gibiansky, Leonid ; Li, Xiaobin ; Li, Chunze ; Agarwal, Priya ; Shemesh, Colby S. ; Shi, Rong ; Dere, Randall C. ; Hirata, Jamie ; Miles, Dale ; Chanu, Pascal ; Girish, Sandhya ; Jin, Jin Yan
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2020-01, Vol.9 (1), p.48-59
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ArticlesPeer ReviewedFull Text
Target-mediated drug disposition model and its approximations for antibody–drug conjugates
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2014-02, Vol.41 (1), p.35-47
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ArticlesPeer ReviewedFull Text
Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2017-10, Vol.44 (5), p.463-475
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ArticlesPeer ReviewedFull Text
Mathematical description of drug–target interactions: application to biologics that bind to targets with two binding sites
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2018-02, Vol.45 (1), p.23-34
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ArticlesPeer ReviewedFull Text
Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach
Author / Creator:Gibiansky, Leonid ; Frey, Nicolas
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.5-16
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ArticlesPeer ReviewedFull Text
Target-mediated drug disposition model for drugs that bind to more than one target
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2010-08, Vol.37 (4), p.323-346
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ArticlesPeer ReviewedFull Text
Target-mediated drug disposition model: relationships with indirect response models and application to population PK–PD analysis
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2009-08, Vol.36 (4), p.341-351
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Model-based pharmacokinetic analysis of elotuzumab in patients with relapsed/refractory multiple myeloma
Author / Creator:Gibiansky, Leonid ; Passey, Chaitali ; Roy, Amit ; Bello, Akintunde ; Gupta, Manish
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2016-06, Vol.43 (3), p.243-257
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Comparison of Nonmem 7.2 estimation methods and parallel processing efficiency on a target-mediated drug disposition model
Author / Creator:Gibiansky, Leonid ; Gibiansky, Ekaterina ; Bauer, Robert
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.17-35
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Showing 1 to 20 of 36 results

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Approximations of the target-mediated drug disposition model and identifiability of model parameters

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Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate

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Population pharmacokinetic and exposure–response analyses of intravenous and subcutaneous rituximab in patients with chronic lymphocytic leukemia

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Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-H...

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Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma

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Exposure-safety and exposure-efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors

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Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

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Population pharmacokinetic analysis for tisotumab vedotin in patients with locally advanced and/or metastatic solid tumors

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Rituximab pediatric drug development: Pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with granulomatosis with polyangiitis or microscopi...

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Ethnic sensitivity assessment: Polatuzumab vedotin pharmacokinetics in Asian and non‐Asian patients with previously untreated diffuse large B‐cell lymphoma in POLARIX

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Population pharmacokinetics and exposure–response analyses of polatuzumab vedotin in patients with previously untreated DLBCL from the POLARIX study

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Integrated Two‐Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non‐Hodgkin Lymphoma

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Target-mediated drug disposition model and its approximations for antibody–drug conjugates

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Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site

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Mathematical description of drug–target interactions: application to biologics that bind to targets with two binding sites

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Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach

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Target-mediated drug disposition model for drugs that bind to more than one target

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Target-mediated drug disposition model: relationships with indirect response models and application to population PK–PD analysis

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Model-based pharmacokinetic analysis of elotuzumab in patients with relapsed/refractory multiple myeloma

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Comparison of Nonmem 7.2 estimation methods and parallel processing efficiency on a target-mediated drug disposition model

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