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Therapeutic siRNA silencing in inflammatory monocytes in mice

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Therapeutic siRNA silencing in inflammatory monocytes in mice

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1008828507

Therapeutic siRNA silencing in inflammatory monocytes in mice

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New York: Nature Publishing Group US

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In vivo
silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner
et al
. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

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Full title

Therapeutic siRNA silencing in inflammatory monocytes in mice

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Record Identifier

TN_cdi_proquest_miscellaneous_1008828507

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1008828507

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ISSN

1087-0156

E-ISSN

1546-1696

DOI

10.1038/nbt.1989

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