Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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This Review chronicles the events that led to an increased understanding of osteoclast biology, the identification of osteoprotegerin (OPG) and the signalling pathway mediated by receptor activator of NF-κB (RANK) and RANK ligand (RANKL), as well as the development of the therapeutic RANKL-targeted antibody denosumab.
OPG was ident...
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Full title
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
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TN_cdi_proquest_miscellaneous_1010493706
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1010493706
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd3705
