IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
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Author / Creator
Sherlock, Jonathan P , Joyce-Shaikh, Barbara , Turner, Scott P , Chao, Cheng-Chi , Sathe, Manjiri , Grein, Jeff , Gorman, Daniel M , Bowman, Edward P , McClanahan, Terrill K , Yearley, Jennifer H , Eberl, Gérard , Buckley, Christopher D , Kastelein, Robert A , Pierce, Robert H , LaFace, Drake M and Cua, Daniel J
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Spondyloarthropathies are characterized by a distinct pattern of inflammation at distinct anatomical sites and are associated with elevated expression of interleukin 23 (IL-23). Daniel Cua and his colleagues identify an IL-23–responsive CD4
−
CD8
−
T cell population located within entheses. Systemic overexpression of IL-23 activates the...
Alternative Titles
Full title
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
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TN_cdi_proquest_miscellaneous_1024351883
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1024351883
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2817
