Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage pol...
Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Notch signaling is known to modulate macrophage polarization. Hu and colleagues show that the Notch–RBP-J axis controls the expression of M1 macrophage–specific genes by promoting translation of the transcription factor IRF8.
Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define...
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Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
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TN_cdi_proquest_miscellaneous_1032893624
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1032893624
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2304
